GOLD COLLAGEN DEFENCE

Descrizione
Integratore alimentare con una formulazione unica di 17 ingredienti attivi. È specialmente formulato per aiutare la pelle a combattere i radicali liberi per prevenire la riduzione del collagene e mantenere la pelle, unghie e capelli sani.

Ingredienti
Vitamina C (acido L-ascorbico), glucosamina cloridrato (glucosamina HCl), estratto secco di tè verde (40% EGCG, Camellia sinensis (L.) Kuntze), vitamina E (alfa-tocoferolo), vitamina B3 (niacina), gluconato di zinco, ialuronato di sodio, coenzima Q10 (ubidecarenone), beta-carotene, vitamina B6 (piridossina cloridrato), vitamina A (retinil acetato), gluconato di rame, estratto di pepe nero (95% piperine - Piper nigrum L.), luteina, astaxantina (soia), L-selenio metionina, vitamina H (biotina); agenti di carica: cellulosa microcristallina, calcio fosfato; antiagglomeranti: magnesio stearato vegetale, biossido di silicio; stabilizzante: carbossimetilcellulosa sodica reticolata; agenti di rivestimento: idrossipropilmetilcellulosa, cellulosa microcristallina, acido stearico; coloranti alimentari: E171, E101, E172.2.

Senza glutine e lattosio.
Adatto a vegetariani e vegani.
Non contiene conservanti, zuccheri e dolcificanti artificiali.

Caratteristiche nutrizionali

Valori medi	Per singolo flacone (50 ml)	VNR*
Vitamina C	80 mg	100%
Glucosamina	30 mg	-
Estratto di tè verde	20 mg	-
Vitamina E (alfa-tocoferolo)	10 mg	83%
Vitamina B3 (niacina)	10 mg	63%
Zinco	10 mg	100%
Acido ialuronico	5 mg	-
Coenzima Q10 (ubidecarenone)	3 mg	-
Beta-carotene	2 mg	-
Vitamina B6	1,5 mg	107%
Vitamina A (RE)	1 mg	125%
Rame	1 mg	100%
Estratto di pepe nero	1 mg	-
Luteina	0,5 mg	-
Astaxantina	0,5 mg	-
Selenio	0,07 mg	127%
Vitamina H (biotina)	0,05 mg	100%

*VNR: valori nutritivi di riferimento

Modalità d'uso
Si consiglia di assumere una compressa al giorno a stomaco pieno o secondo indicazione del medico per almeno un mese, preferibilmente per un periodo più lungo per ottenere risultati più duraturi.

Avvertenze
Non superare la dose giornaliera raccomandata. Tenere fuori dalla portata dei bambini al di sotto dei 3 anni di età. Gli integratori non vanno intesi come sostituti di una dieta variata. Consultare il medico curante prima di assumere il prodotto in caso si stiano assumendo già altri integratori alimentari o in caso di allergie alimentari, di assunzione di farmaci o se sottoposti a cure mediche. Consultare il medico se si osserva una reazione indesiderata. Consultare il medico in caso di stato di gravidanza o allattamento prima di assumere Gold Collagen Defence.

Conservazione
Conservare ad una temperatura inferiore a 30°C, lontano dalla luce diretta del sole e dal calore e proteggere dall'umidità. La data di scadenza si riferisce al prodotto conservato correttamente con la confezione integra.
Validità a confezionamento integro: 24 mesi

Formato
Confezione da 30 compresse

Bibliografia
Baumann L: Skin ageing and its treatment. The Journal of pathology 2007, 211:241- 51.
Guercio-Hauer C, Macfarlane DF, Deleo VA: Photodamage, photoaging and photoprotection of the skin. American family physician 1994, 50:327-32, 34.
Thiele JJ: Oxidative targets in the stratum corneum. A new basis for antioxidative strategies. Skin pharmacology and applied skin physiology 2001, 14 Suppl 1:87-91.
Levine RL, Stadtman ER: Oxidative modification of proteins during ageing. Experimental gerontology 2001, 36:1495-502.
Bickers DR, Athar M: Oxidative stress in the pathogenesis of skin disease. The Journal of investigative dermatology 2006, 126:2565-75.
Rani AJ, Mythili SV: Study on total antioxidant status in relation to oxidative stress in type 2 diabetes mellitus. Journal of clinical and diagnostic research: JCDR 2014, 8:108-10.
Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO, 3rd, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Reda DJ, Moskowitz RW, Williams HJ, Clegg DO: The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis and rheumatism 2008, 58:3183-91.
Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO, 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR, Jr., Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ: Glucosamine, chondroitin sulphate, and the two in combination for painful knee osteoarthritis. The New England journal of medicine 2006, 354:795-808.
Murad H, Tabibian MP: The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneousageing: a preliminary study. The Journal of dermatological treatment 2001, 12:47-51.
Yuan JP, Peng J, Yin K, Wang JH: Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Molecular nutrition & food research 2011, 55:150-65.
Miki W: Biological functions and activities of animal carotenoids. Pure and Applied Chemistry 1991, 63 141–6.
Matsuno T: Xanthophylls as precursors of retinoids. Pure and Applied Chemistry 1991, 63: 81–8.
Lee SJ, Bai SK, Lee KS, Namkoong S, Na HJ, Ha KS, Han JA, Yim SV, Chang K, Kwon YG, Lee SK, Kim YM: Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappa B activation. Molecules and cells 2003, 16:97-105.
Goto S, Kogure K, Abe K, Kimata Y, Kitahama K, Yamashita E, Terada H: Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochimica et biophysica acta 2001, 1512:251-8.
Yamashita E: Suppression of post-UVB hyperpigmentation by topical astaxanthin from krill. Fragrance Journal 1995, 14:180–5.
Arakane K: Superior skin protection via astaxanthin. Carotenoid Science 2002, 5:21–4.
Hama S, Takahashi K, Inai Y, Shiota K, Sakamoto R, Yamada A, Tsuchiya H, Kanamura K, Yamashita E, Kogure K: Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage. Journal of pharmaceutical sciences 2012, 101:2909-16.
Biswal S: Oxidative stress and astaxanthin: The novel supernutrient carotenoid. International Journal of Health & Allied Sciences 2014, 3:147-53.
Cho S, Lee DH, Won CH, Kim SM, Lee S, Lee MJ, Chung JH: Differential effects of low-dose and high-dose beta-carotene supplementation on the signs of photoaging and type I procollagen gene expression in human skin in vivo. Dermatology 2010, 221:160-71.
Lee J, Jiang S, Levine N, Watson RR: Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proceedings of the Society for Experimental Biology and Medicine Society for Experimental Biology and Medicine 2000, 223:170-4.
Kopcke W, Krutmann J: Protection from sunburn with beta-Carotene--a metaanalysis. Photochemistry and photobiology 2008, 84:284-8.
Littarru GP, Tiano L: Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular biotechnology 2007, 37:31-7.
Inui M, Ooe M, Fujii K, Matsunaka H, Yoshida M, Ichihashi M: Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. BioFactors 2008, 32:237-43.
Zhang M, Dang L, Guo F, Wang X, Zhao W, Zhao R: Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1alpha production and melanin synthesis in vitro. International journal of cosmetic science 2012, 34:273-9.
Muta-Takada K, Terada T, Yamanishi H, Ashida Y, Inomata S, Nishiyama T, Amano S: Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells. BioFactors 2009, 35:435-41.
Forester SC, Lambert JD: The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Molecular nutrition & food research 2011, 55:844-54.
Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM: Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evidence-based complementary and alternative medicine : eCAM 2005, 2:301-8.
Lacroix S, Bouez C, Vidal S, Cenizo V, Reymermier C, Justin V, Vicanova J, Damour O: Supplementation with a complex of active nutrients improved dermal and epidermal characteristics in skin equivalents generated from fibroblasts from young or aged donors. Biogerontology 2007, 8:97-109.
Madhan B, Krishnamoorthy G, Rao JR, Nair BU: Role of green tea polyphenols in the inhibition of collagenolytic activity by collagenase. International journal of biological macromolecules 2007, 41:16-22.
Katiyar SK: Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Current drug targets Immune, endocrine and metabolic disorders 2003, 3:234-42.
Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE, Kimball AB: Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al] 2005, 31:855- 60; discussion 60.
Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M: Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. Journal of agricultural and food chemistry 2010, 58:835-41.
Aito-Inoue M, Lackeyram D, Fan MZ, Sato K, Mine Y: Transport of a tripeptide, Gly-Pro-Hyp, across the porcine intestinal brush-border membrane. Journal of peptide science: an official publication of the European Peptide Society 2007, 13:468-74.
Toshihide S: Clinical effects of dietary hyaluronic acid on dry, rough skin. . Aesthetic Dermatology 2002, 12:109-20.
Kawada C, Yoshida T, Yoshida H, Matsuoka R, Sakamoto W, Odanaka W, Sato T, Yamasaki T, Kanemitsu T, Masuda Y, Urushibata O: Ingested hyaluronan moisturizes dry skin. Nutrition journal 2014, 13:70.
Roberts RL, Green J, Lewis B: Lutein and zeaxanthin in eye and skin health. Clinics in dermatology 2009, 27:195-201.
Gonzalez S, Astner S, An W, Goukassian D, Pathak MA: Dietary lutein/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice. The Journal of investigative dermatology 2003, 121:399-405.
Lee EH, Faulhaber D, Hanson KM, Ding W, Peters S, Kodali S, Granstein RD: Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. The Journal of investigative dermatology 2004, 122:510-7.
Palombo P, Fabrizi G, Ruocco V, Ruocco E, Fluhr J, Roberts R, Morganti P: Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin pharmacology and physiology 2007, 20:199-210.